Publications
Reversal of Catalytic Material Substrate Selectivity through Partitioning of Polymers in Hierarchically Ordered Virus-like Particle Frameworks.
Kraj, P., Hewagama, N. D., Lee, B., Douglas, T. Reversal of Catalytic Material Substrate Selectivity through Partitioning of Polymers in Hierarchically Ordered Virus-like Particle Frameworks. Chem. Mater. (2023). DOI: 10.1021/acs.chemmater.3c02053
Higher-Order VLP-Based Protein Macromolecular Framework Structures Assembled via Coiled-Coil Interactions
Hewagama, N. D., Uchida, M., Wang, Y., Kraj, P., Lee, B., Douglas, T. Higher-Order VLP-Based Protein Macromolecular Framework Structures Assembled via Coiled-Coil Interactions. Biomacromolecules. (2023). DOI: 10.1021/acs.biomac.3c00410
Enhancing Multistep Reactions: Biomimetic Design of Substrate Channeling Using P22 Virus-Like Particles
Wang, Y., Selivanovitch, E., Douglas, T. Enhancing Multistep Reactions: Biomimetic Design of Substrate Channeling Using P22 Virus-Like Particles. Advanced Science. (2023). DOI: 10.1002/advs.202206906
Tunable In Vivo Colocalization of Enzymes within P22 Capsid-Based Nanoreactors
McNeale, D., Esquirol, L., Okada, S., Strampel, S., Dashti, N., Rehm, B., Douglas, T., Vickers, C. E., Sainsbury, F. Tunable In Vivo Colocalization of Enzymes within P22 Capsid-Based Nanoreactors. ACS Appl. Mater. Interfaces (2023). DOI: 10.1021/acsami.3c00971
Diffusion and molecular partitioning in hierarchically complex virus-like particles
Kraj, P., Hewagama, N. D., Douglas, T. Diffusion and molecular partitioning in hierarchically complex virus-like particles. Virology. (2023). DOI: 10.1016/j.virol.2023.01.012
Tuning properties of biocatalysis using protein cage architectures
Wang, Y., Douglas, T. Tuning properties of biocatalysis using protein cage architectures. J Mat. Chem. B (2023). DOI: 10.1039/D3TB00168G
Rapid Assembly and Prototyping of Biocatalytic Virus-like Particle Nanoreactors
Esquirol, L., McNeale, D., Douglas, T., Vickers, C. E., Sainsbury, F. Rapid Assembly and Prototyping of Biocatalytic Virus-like Particle Nanoreactors. ACS Synth. Biol. (2022). DOI: 10.1021/acssynbio.2c00117
Electromechanical Photophysics of GFP Packed Inside Viral Protein Cages Probed by Force-Fluorescence Hybrid Single-Molecule Microscopy
Strobl, K., Selivanovitch, E., Ibáñez-Freire, P., Moreno-Madrid, F., Schaap, I. A. T., Delgado-Buscalioni, R., Douglas, T., de Pablo P. J. Electromechanical Photophysics of GFP Packed Inside Viral Protein Cages Probed by Force-Fluorescence Hybrid Single-Molecule Microscopy. Small. (2022) DOI: 10.1002/smll.202200059
Multilayered Ordered Protein Arrays Self-Assembled from a Mixed Population of Virus-like Particles
Uchida, M., Brunk, N. E., Hewagama, N. D., Lee, B., Prevelige, P., Jadhao, V., Douglas, T. Multilayered Ordered Protein Arrays Self-Assembled from a Mixed Population of Virus-like Particles. ACS Nano. (2022). DOI: 10.1021/acsnano.1c11272
Bioinspired Approaches to Self-Assembly of Virus-like Particles: From Molecules to Materials
Wang, Y., Douglas, T. Bioinspired Approaches to Self-Assembly of Virus-like Particles: From Molecules to Materials. Acc. Chem. Res. (2022). DOI: 10.1021/acs.accounts.2c00056
Controlled Modular Multivalent Presentation of the CD40 Ligand on P22 Virus-like Particles Leads to Tunable Amplification of CD40 Signaling
Goodall, C.P., Schwartz, B., Selivanovitch, E., Avera, J., Wang, J., Miettinen, H., Douglas, T. Controlled Modular Multivalent Presentation of the CD40 Ligand on P22 Virus-like Particles Leads to Tunable Amplification of CD40 Signaling. ACS Appl. Bio. Mater. (2021). DOI: 10.1021/acsabm.1c00718
Substrate Partitioning into Protein Macromolecular Frameworks for Enhanced Catalytic Turnover
Selivanovitch, E., Uchida, M., Lee, B., Douglas, T. Substrate Partitioning into Protein Macromolecular Frameworks for Enhanced Catalytic Turnover. ACS Nano (2021). DOI: 10.1021/acsnano.1c05004
Molecular exclusion limits for diffusion across a porous capsid
Selivanovitch, E., LaFrance, B., Douglas, T. Molecular exclusion limits for diffusion across a porous capsid. Nature Communications (2021). DOI: 10.1038/s41467-021-23200-1
Polymer Coatings on Virus-like Particle Nanoreactors at Low Ionic Strength—Charge Reversal and Substrate Access
Kraj, P., Selivanovitch, E., Lee, B., Douglas, T. Polymer Coatings on Virus-like Particle Nanoreactors at Low Ionic Strength—Charge Reversal and Substrate Access. Biomacromolecules (2021). DOI: 10.1021/acs.biomac.1c00208
Cytochrome C with peroxidase-like activity encapsulated inside the small DPS protein nanocage
Waghwani, H. K., Douglas, T. Cytochrome C with peroxidase-like activity encapsulated inside the small DPS protein nanocage. Journal of Materials Chemistry B (2021). DOI: 10.1039/D1TB00234A
Synthetic Virus-like Particles for Glutathione Biosynthesis
Wang, Y., Uchida, M., Waghwani, H. K., Douglas, T. Synthetic Virus-like Particles for Glutathione Biosynthesis. ACS Synthetic Biology (2020). DOI: 10.1021/acssynbio.0c00368
Protein nanocage architectures for the delivery of therapeutic proteins
Wang, Y., Douglas, T. Protein nanocage architectures for the delivery of therapeutic proteins. Current Opinion in Colloid & Interface Science (2020). DOI: 10.1016/j.cocis.2020.101395
Virus-Like Particles (VLPs) as a Platform for Hierarchical Compartmentalization
Waghwani, H. K., Uchida, M., Fu, C., LaFrance, B., Sharma, J., McCoy, K., Douglas, T. Virus-Like Particles (VLPs) as a Platform for Hierarchical Compartmentalization. Biomacromolecules (2020). DOI: 10.1021/acs.biomac.0c00030
A Self-Adjuvanted, Modular, Antigenic VLP for Rapid Response to Influenza Virus Variability
Sharma, J., Shepardson, K., Johns, L. L., Wellham, J., Avera, J., Schwartz, B., Rynda-Apple, A., Douglas, T. A Self-Adjuvanted, Modular, Antigenic VLP for Rapid Response to Influenza Virus Variability. ACS Applied Materials & Interfaces (2019). DOI: 10.1021/acsami.9b21776
Tuning the catalytic properties of P22 nanoreactors through compositional control
Sharma, J., Douglas, T. Tuning the catalytic properties of P22 nanoreactors through compositional control. Nanoscale (2019). DOI: 10.1039/C9NR08348K
The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration
Uchida, M., Maier, B., Waghwani, H. K., Selivanovitch, E., Pay, S.E., Avera, J., Yun, E., Sandoval, R. M., Molitoris, B. A., Zollman, A., Douglas, T., Hato, T. The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration. Journal of Clinical Investigation (2019). DOI: 10.1172/JCI127511
Virus capsid assembly across different length scales inspire the development of virus-based biomaterials
Selivanovitch, E., Douglas, T. Virus capsid assembly across different length scales inspire the development of virus-based biomaterials. Current Opinion in Virology (2019). DOI: 10.1016/j.coviro.2019.02.010
Linker-Mediated Assembly of Virus-Like Particles into Ordered Arrays via Electrostatic Control
Nicholas E. Brunk, N. E., Uchida, M., Lee, B., Fukuto, M., Yang, L., Douglas, T., Jadhao, V. Linker-Mediated Assembly of Virus-Like Particles into Ordered Arrays via Electrostatic Control. ACS Applied Bio Materials (2019). DOI: 10.1021/acsabm.9b00166
Loading the Dice: The Orientation of Virus-Like Particles Adsorbed on Titanate Assisted Organosilanized Surfaces
Moreno-Cerrada, D., Rodríguez, C., Moreno-Madrid, F., Selivanovitch, E., Douglas, T., de Pablo, P. J., Manso Silván, M. Loading the Dice: The Orientation of Virus-Like Particles Adsorbed on Titanate Assisted Organosilanized Surfaces. Biointerphases (2019). DOI: 10.1116/1.5077010
Chemically Induced Morphogenesis of P22 Virus like Particles by the Surfactant Sodium Dodecyl Sulfate
Selivanovitch, E., Koliyatt, R., Douglas, T. Chemically Induced Morphogenesis of P22 Virus like Particles by the Surfactant Sodium Dodecyl Sulfate. Biomacromolecules (2018). DOI: 10.1021/acs.biomac.8b01357
Cargo Retention inside P22 Virus-Like Particles
McCoy, K., Selivanovitch, E., Luque, D., Lee, B., Edwards, E., Castón, J. R., Douglas, T. Cargo Retention inside P22 Virus-Like Particles. Biomacromolecules (2018). DOI: 10.1021/acs.biomac.8b00867
Changes in the Stability and Biomechanics of P22 Bacteriophage Capsid During Maturation
Kant, R., Llauró, A., Vamseedhar, R., Qazi, S., de Pablo, P. D., Douglas, T., Bothner, B. Changes in the Stability and Biomechanics of P22 Bacteriophage Capsid During Maturation. Biochimica et Biophysica Acta – General Subjects (2018). DOI: 10.1016/j.bbagen.2018.03.006
Protein cage assembly across multiple length scales
Aumiller, Jr., W.M., Uchida, M. and Douglas, T. Protein cage assembly across multiple length scales. Chem. Soc. Rev. (2018). DOI: 10.1039/C7CS00818J
Stimuli Responsive Hierarchical Assembly of P22 Virus-like Particles
Aumiller Jr., W.M., Uchida, M., Biner, D.W., Miettinen, H.M., Lee, B., and Douglas, T. Stimuli Responsive Hierarchical Assembly of P22 Virus-like Particles. Chem. Mater. (2018). DOI: 10.1021/acs.chemmater.7b04964
Templated Assembly of a Functional Ordered Protein Macromolecular Framework from P22 Virus-like Particles
McCoy, K., Uchida, M., Lee, B., and Douglas, T. Templated Assembly of a Functional Ordered Protein Macromolecular Framework from P22 Virus-like Particles (2018). ACS Nano. DOI: 10.1021/acsnano.8b00528
Induction of Antiviral Immune Response through Recognition of the Repeating Subunit Pattern of Viral Capsids Is Toll-Like Receptor 2 Dependent.
Shepardson KM, Schwarz B, Larson K, Morton RV, Avera J, McCoy K, Caffrey A, Harmsen A, Douglas T, and Rynda-Apple A. Induction of Antiviral Immune Response through Recognition of the Repeating Subunit Pattern of Viral Capsids Is Toll-Like Receptor 2 Dependent. MBio (2017). Doi: 10.1128/mBio.01356-17
Modular Self-Assembly of Protein Cage Lattices for Multistep Catalysis.
Uchida M, McCoy K, Fukuto M, Yang L, Yoshimura H, Miettinen HM, LaFrance B, Patterson DP, Schwarz B, Karty JA, Prevelige PE Jr, Lee B, and Douglas T. Modular Self-Assembly of Protein Cage Lattices for Multistep Catalysis. ACS nano (2017). DOI: 10.1021/acsnano.7b06049
Biomedical and Catalytic Opportunities of Virus-Like Particles in Nanotechnology
Schwarz B, Uchida M, Douglas T. Biomedical and Catalytic Opportunities of Virus-Like Particles in Nanotechnology. Advances in Virus Research (2017). DOI: 10.1016/bs.aivir.2016.09.002.
Modular interior loading and exterior decoration of a virus-like particle
Sharma J, Uchida M, Miettinen HM, Douglas T. Modular interior loading and exterior decoration of a Virus-like particle. Nanoscale (2017). DOI: 10.1039/C7NR03018E
Sortase-Mediated Ligation as a Modular Approach for the Covalent Attachment of Proteins to the Exterior of the Bacteriophage P22 Virus-like Particle
Patterson DP, Schwarz B, Avera J, Western B, Hicks M, Krugler P, Terra M, Uchida M, McCoy K, Douglas T. Sortase-Mediated Ligation as a Modular Approach for the Covalent Attachment of Proteins to the Exterior of the Bacteriophage P22 Virus-like Particle. Bioconjugate Chemistry (2017). DOI: 10.1042/BST20160316
Atomic force microscopy of virus shells
Moreno-Madrid F, Martín-González N, Llauró A, Ortega-Esteban A, Hernando-Pérez M, Douglas T, Schaap IA, de Pablo PJ. Atomic force microscopy of virus shells. Biochemical Society Transactions (2017). DOI: 10.1042/BST20160316
RGD targeting of human ferritin iron oxide nanoparticles enhances in vivo MRI of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm
Kitagawa T, Kosuge H, Uchida M, Iida Y, Dalman RL, Douglas T, McConnell MV. RGD targeting of human ferritin iron oxide nanoparticles enhances in vivo MRI of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm. Journal of Magnetic Resonance Imaging (2017). DOI: 10.1002/jmri.25459
Virus Matryoshka: A Bacteriophage Particle-Guided Molecular Assembly Approach to a Monodisperse Model of the Immature Human Immunodeficiency Virus
Pooja Saxena, Li He, Andrey Malyutin, Siddhartha A. K. Datta, Alan Rein, Kevin M. Bond, Martin F. Jarrold, Alessandro Spilotros, Dmitri Svergun, Trevor Douglas, Bodgan Dragnea “Virus Matryoshka: A Bacteriophage Particle-Guided Molecular Assembly Approach to a Monodisperse Model of the Immature Human Immunodeficiency Virus” Small (2016). DOI: 10.1002/smll.201601712
Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses
Benjamin Schwarz, Kaitlyn M. Morabito, Tracy J. Ruckwardt, Dustin P. Patterson, John Avera,
Heini M. Miettinen, Barney S. Graham, and Trevor Douglas. “Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses”. ACS Biomater. Sci. Eng.(2016) DOI: 10.1021/acsbiomaterials.6b00532
Tuning Viral Capsid Nanoparticle Stability with Symmetrical Morphogenesis
Aida Llauró, Benjamin Schwarz, Ranjit Koliyatt, Pedro J. de Pablo, and Trevor Douglas “Tuning Viral Capsid Nanoparticle Stability with Symmetrical Morphogenesis” ACS Nano (2016) DOI: 10.1021/acsnano.6b03441.
Co-localization of Catalysts within a Protein Cage Leads to Efficient Photochemical NADH and/or Hydrogen Production
Ethan Edwards, Rajarshi Roychoudhury,Benjamin Schwarz, Paul Jordan, John Lisher, Masaki Uchida and Trevor Douglas “Co-localization of Catalysts within a Protein Cage Leads to Efficient Photochemical NADH and/or Hydrogen Production” Journal of Materials Chemistry B (2016) DOI: 10.1039/c6tb01175f.
Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity
Basmah A. Othman, Christina Greenwood, Ayman F. Abuelela, Anil A. Bharath, Shu Chen, Ioannis Theodorou, Trevor Douglas, Maskai Uchida, Mary Ryan, Jasmeen S. Merzaban, Alexandra E. Porter “Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity” Advanced Healthcare Materials (2016). DOI: 10.1002/adhm.201670053
Two-Dimensional Crystallization of P22 Virus-Like Particles
Hideyuki Yoshimura, Ethan Edwards, Masaki Uchida, Kimberly McCoy, Raj Roychoudhury, Benjamin Schwarz, Dustin Patterson, and Trevor Douglas “Two-Dimensional Crystallization of P22 Virus-Like Particles” Journal of Physical Chemistry B (2016). DOI: 10.1021/acs.jpcb.6b01425
Cargo–shell and cargo–cargo couplings govern the mechanics of artificially loaded virus-derived cages
Aida Llauró, Daniel Luque, Ethan Edwards, Benes L. Trus, John Avera, David Reguera, Trevor Douglas, Pedro J. de Pablo and José R. Castón “Cargo–shell and cargo–cargo couplings govern the mechanics of artificially loaded virus-derived cages” Nanoscale (2016).
Programmed Self-Assembly of an Active P22-Cas9 Nanocarrier System
Shefah Qazi, Heini M. Miettinen, Royce A. Wilkinson, Kimberly McCoy, Trevor Douglas, and Blake Wiedenheft. “Programmed Self-Assembly of an Active P22-Cas9 Nanocarrier System.” Molecular Pharmaceutics (2016).
Developing a Dissociative Nanocontainer for Peptide Drug Delivery
Patrick Kelly, Prachi Anand, Alexander Uvaydov, Srinivas Chakravartula, Chhime Sherpa, Elena Pires, Alison O’Neil, Trevor Douglas and Mande Holford “Developing a Dissociative Nanocontainer for Peptide Drug Delivery” International Journal of Environmental Research and Public Health (2015) DOI: 10.3390/ijerph121012543
Self-assembling biomolecular catalysts for hydrogen production
Paul C. Jordan, Dustin P. Patterson, Kendall N. Saboda, Ethan J. Edwards, Heini M. Miettinen, Gautam Basu, Megan C. Thielges and Trevor Douglas. “Self-assembling biomolecular catalysts for hydrogen production.” Nature Chemistry (2015).
Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery
Sánchez-Sánchez, Lorena, et al. “Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery.” Journal of Nanobiotechnology 13.1 (2015): 66.
Symmetry Controlled, Genetic Presentation of Bio-Active Proteins on the P22 Virus-Like Particle Using an External Decoration Protein
B. Schwarz, P. Madden, J. Avera, B. Gordon, K. Larson, H. Miettinen, M. Uchida, B. LaFrance, G. Basu, A. Rynda-Apple, and T. Douglas.”Symmetry Controlled, Genetic Presentation of Bio-Active Proteins on the P22 Virus-Like Particle Using an External Decoration Protein” ACS Nano (2015) DOI: 10.1021/acsnano.5b03360
Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers
P. Anand, A. O’Neil, E. Lin, T. Douglas, M. Holford, M. “Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers” Scientific Reports (2015) DOI: 10.1038/srep12497.
Interligand Electron Transfer in Heteroleptic Ruthenium(II) Complexes Occurs on Multiple Time Scales
C. Stark, W. Schreier, J. Lucon, E. Edwards, T. Douglas, B. Kohler, “Interligand Electron Transfer in Heteroleptic Ruthenium(II) Complexes Occurs on Multiple Time Scales” The Journal of Physical Chemistry, Part A (2015) 119, 4813-4824.
Selective Biotemplated Synthesis of TiO2 Inside a Protein Cage.
Gregory J. Bedwell, Ziyou Zhou, Masaki Uchida, Trevor Douglas, Arunava Gupta, and Peter E. Prevelige, Jr.”Selective Biotemplated Synthesis of TiO2 Inside a Protein Cage” Biomacromolecules (2015) 16, 214-218.
Development of virus‐like particles for diagnostic and prophylactic biomedical applications.
Benjamin Schwarz and Trevor Douglas “Development of virus-like particles for diagnostic and prophylactic biomedical applications” WIREs Nanomed Nanobiotechnol (2015) doi: 10.1002/wnan.1336
Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents.
Robert J. Usselman, Shefah Qazi, Priyanka Aggarwal, Sandra S. Eaton, Gareth R.Eaton, Stephen Russek and Trevor Douglas “Gadolinium-loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents”, Applied Magnetic Resonance (2015) 46, 349-355.
Use of Protein Cages as a Template for Confined Synthesis of Inorganic and Organic Nanoparticles.
Uchida, M., Qazi, S., Edwards, E., & Douglas, T. (2015). Use of Protein Cages as a Template for Confined Synthesis of Inorganic and Organic Nanoparticles. In Protein Cages (pp. 17-25). Springer New York.
Higher order assembly of virus-like particles (VLP) mediated by multi-valent protein linkers
Masaki Uchida, Benjamin LaFrance, Chris C. Broomell, Peter E. Prevelige, Trevor Douglas “Higher order assembly of virus-like particles (VLP) mediated by multi-valent protein linkers” Small (2015) 13, 1562-1570 DOI: 10.1002/smll.201402067
Constructing Catalytic Antimicrobial Nanoparticles by Encapsulation of Hydrogen Peroxide Producing Enzyme Inside the P22 VLP
Dustin P. Patterson, Kimberly McCoy, Carel Fijen, and Trevor Douglas “Constructing Catalytic Antimicrobial Nanoparticles by Encapsulation of Hydrogen Peroxide Producing Enzyme Inside the P22 VLP” J. Materials Chemistry B (2014) 2, 5948-5951.
Hybrid Nanoreactors: Coupling Enzymes and Small-Molecule Catalysts within Virus-Like Particles
Dustin Patterson, Ethan Edwards, and Trevor Douglas “Hybrid Nanoreactors: Coupling Enzymes and Small-Molecule Catalysts within Virus-Like Particles” Israel J. Chem (2014) DOI: 10.1002/ijch.201400092.
X-Ray Spatial Frequency Heterodyne Imaging of Protein-Based Nanobubble Contrast Agents
Danielle Rand, Masaki Uchida, Trevor Douglas, Christoph Rose-Petruck, “X-Ray Spatial Frequency Heterodyne Imaging of Protein-Based Nanobubble Contrast Agents”, Optics Express (2014) 22, 23290-23298. DOI:10.1364/OE.22.023290.
Virus-like particles as antigenic nanomaterials for inducing protective immune responses in the lung
Agnieszka Rynda-Apple, Dustin Patterson, Trevor Douglas, “Virus-like particles as antigenic nanomaterials for inducing protective immune responses in the lung” Nanomedicine (2014) 9,1857-1868, DOI 10.2217/nnm.14.107.
Manganese (III) porphyrins complexed with P22 virus-like particles as T1-enhanced contrast agents for magnetic resonance imaging (MRI)
Shefah Qazi, Masaki Uchida, Robert Usselman, Riley Shearer, Ethan Edwards, and Trevor Douglas “Manganese (III) porphyrins complexed with P22 virus-like particles as T1-enhanced contrast agents for magnetic resonance imaging (MRI)” JBIC (2014) 19, 237-246.
Encapsulation of an Enzyme Cascade Within the Bacteriophage P22 Virus-Like Particle
Dustin P. Patterson, Benjamin Schwarz, Ryan Waters, Tomas Gedeon, Trevor Douglas “Encapsulation of an Enzyme Cascade Within the Bacteriophage P22 Virus-Like Particle” ACS Chemical Biology (2014) 9, 359–365. DOI:10.1021/cb300388w.
CD11c+ cells primed with unrelated antigens facilitate an accelerated immune response to influenza virus in mice
Laura E. Richert, Agnieszka Rynda-Apple, Ann L. Harmsen, Soo Han, James A. Wiley, Trevor Douglas, Kyle Larson, Rachelle V. Morton, Allen G. Harmsen “CD11c+ cells primed with unrelated antigens facilitate an accelerated immune reponse to influenza virus in mice” European Journal of Immunology (2014) 44, 397–408.
Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Synergizes with Local Lymph Nodes during Antiviral CD4+ T Cell Responses
Laura E. Richert, Ann L. Harmsen, Agnieszka Rynda-Apple, James A. Wiley, Amy Servid, Trevor Douglas, Allen G. Harmsen “Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Synergizes with Local Lymph Nodes during Antiviral CD4+ T Cell Responses” Lymphatic Research and Biology (2013) 11,196-202. doi: 10.1089/lrb.2013.0015.
Rescuing Recombinant Proteins by Sequestration Into the P22 VLP
Dustin P. Patterson, Benjamin LaFrance and Trevor Douglas “Rescuing Recombinant Proteins by Sequestration Into the P22 VLP” Chemical Communications (2013) DOI: 10.1039 / C3CC46517A.
P22 viral capsids as nanocomposite high-relaxivity MRI contrast agents
Shefah Qazi, Lars O. Liepold, Md Joynal Abedin, Ben Johnson, Peter Prevelige, Joseph A. Frank, Trevor Douglas “P22 viral capsids as nanocomposite high-relaxivity MRI contrast agents” Molecular Pharmaceutics (2013) 10, 11-17. DOI: 10.1021 / mp300208g.
Biomimetic Antigenic Nanoparticles Elicit Controlled Protective Immune Response to Influenza
Dustin Patterson, Agnieszka Rynda-Apple, Ann Harmsen, Allen G. Harmsen, Trevor Douglas “Biomimetic Antigenic Nanoparticles Elicit Controlled Protective Immune Response to Influenza” ACS Nano (2013) 7, 3036-3044 DOI: 10.102/nn4006544
Stabilizing viral nano-reactors for nerve agent degradation
Alison O’Neil, Peter E. Prevelige, Trevor Douglas, “Stabilizing viral nano-reactors for nerve agent degradation” Biomaterials Science (2013), 1, 881-886. DOI: 10.1039 / C3BM60063G.
Atom Transfer Radical Polymerization on the Interior of the P22 Capsid and Incorporation of Photocatalytic Monomer Crosslinks
Janice Lucon, Ethan Edwards, Shefah Qasi, Masaki Uchida, Trevor Douglas “Atom Transfer Radical Polymerization on the Interior of the P22 Capsid and Incorporation of Photocatalytic Monomer Crosslinks” Eur. Polymer Journal (2013), 49, 2976-2985.
Biophysical Chemistry: Unravelling capsid transformations
Masaki Uchida and Trevor Douglas “Biophysical Chemistry: Unravelling capsid transformations” Nature Chemistry (2013) 5, 444-445.
Location of the Bacteriophage P22 Coat Protein C-terminus Provides Opportunities for the Design of Capsid Based Materials
Amy Servid, Paul Jordan, Alison O’Neil, Peter Prevelige, Trevor Douglas “Location of the Bacteriophage P22 Coat Protein C-terminus Provides Opportunities for the Design of Capsid Based Materials” Biomacromolecules (2013) 14, 2989–2995.
RGD-Conjugated Human Ferritin Nanoparticles for Imaging Vascular Inflammation and Angiogenesis in Experimental Carotid and Aortic Disease
Toshiro Kitagawa, Hisanori Kosuge, Masaki Uchida, Monica M. Dua, Yasunori Iida, Ronald L. Dalman, Trevor Douglas, Michael V. McConnell “RGD-Conjugated Human Ferritin Nanoparticles for Imaging Vascular Inflammation and Angiogenesis in Experimental Carotid and Aortic Disease” Molecular Imaging and Biology (2012) DOI: 10.1007/s11307-011-0495-1
Co-Confinement of Fluorescent Proteins: Spatially Enforced Communication of GFP and mCherry Encapsulated Within the P22 Capsid
Alison O’Neil, Peter E. Prevelige, Gautam Basu, Trevor Douglas, “Co-Confinement of Fluorescent Proteins: Spatially Enforced Communication of GFP and mCherry Encapsulated Within the P22 Capsid” Biomacomolecules (2012) 13, 3902-3907 DOI: 10.1021/bm301347x
Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading
Janice Lucon, Shefah Qazi, Masaki Uchida, Greg Bledwell, Ben LaFrance, Peter Prevelige, and Trevor Douglas “Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading” Nature Chemistry (2012) 4, 781-788.
Nanoreactors by Programmed Enzyme Encapsulation Inside the Capsid of the Bacteriophage P22
Dustin Patterson, Peter E. Prevelige, Trevor Douglas “Nanoreactors by Programmed Enzyme Encapsulation Inside the Capsid of the Bacteriophage P22” ACS Nano (2012) 6, 5000-5009 DOI: 10.1021/nn300545z
Virus-like Particle Nanoreactors: Programmed Encapsulation of the Thermostable CelB Glycosidase Inside the P22 Capsid
Dustin Patterson, Benjamin Schwartz, Trevor Douglas “Virus-like Particle Nanoreactors: Programmed Encapsulation of the Thermostable CelB Glycosidase Inside the P22 Capsid” Soft Matter (2012), 8, 10158-10166.
Topological biosignatures: Large-scale structure of chemical networks from biology and astrochemistry
C. Jolley, T. Douglas “Topological biosignatures: Large-scale structure of chemical networks from biology and astrochemistry” Astrobiology (2012) 12, 29-39.
Characterization of the Bacteroides Fragilis bfr Gene Product Identifies a Bacterial DPS-like Protein and Suggests Evolutionary Links in the Ferritin Superfamily
George H. Gauss, Michael Reott, Edson Rocha, Mark J. Young, Trevor Douglas, C. Smith, C. Martin Lawrence “Characterization of the Bacteroides fragilis bfr Gene Product Identifies a Bacterial DPS-like Protein and Suggests Evolutionary Links in the Ferritin Superfamily” J. Bacteriology (2012) 194, 15-27.
Site directed coordination chemistry with P22 virus like particles
Masaki Uchida, David S. Morris, Sebyung Kang Craig C. Jolley, Janice Lucon, Lars O. Liepold, Ben LaFrance, Peter E. Prevelige, Jr. and Trevor Douglas “Site directed coordination chemistry with P22 virus like particles” Langmuir (2012) 28, 1998-2006.
Proteomic Analysis of Sulfolobus solfataricus During Sulfolobus Turreted Icosahedral Virus Infection
W.S. Maaty, K. Selvig, S. Ryder, P. Tarlykov, J.K. Hilmer, J. Heinemann, J. Steffens, J.C. Snyder, A.C. Ortmann, N. Movahed, K. Spicka, L. Chetia, P.A. Grieco, E.A. Dratz, T. Douglas, M.J. Young, B. Bothner “Proteomic Analysis of Sulfolobus solfataricus During Sulfolobus Turreted Icosahedral Virus Infection” Journal of Proteome Research (2012) 11, 1420-1432.
Photoinduced H2 production by stable [Ni-Fe]-hydrogenases from T. roseopersicina covalently linked to a Ru(II) photosensitizer
Oleg A. Zadvornyy, Janice E. Lucon, Robin Gerlach, Nikolay A. Zorin, Trevor Douglas, Timothy E. Elgren, and John W. Peters “Photoinduced H2 production by stable [Ni-Fe]-hydrogenases from T. roseopersicina covalently linked to a Ru(II) photosensitizer” Journal of Inorganic Biochemistry (2012) 106, 151-155.
A Virus-Like Particle Vaccine Platform Elicits Heightened and Hastened Local Lung Mucosal Antibody Production after a Single Dose
Laura E. Richert, Amy E. Servid, Ann L. Harmsen, Soo Han, James A. Wiley, Trevor Douglas, Allen G. Harmsen “A Virus-Like Particle Vaccine Platform Elicits Heightened and Hastened Local Lung Mucosal Antibody Production after a Single Dose” Vaccine (2012) 30, 3653–3665.
Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function
Agnieszka Rynda-Apple, Erin Dobrinen, Mark McAlpine, Amanda Read, Ann Harmsen, Laura E. Richert, Matthew Calverley, Kyler Pallister, Jovanka Voyich-Kane, James A. Wiley, Ben Johnson, Mark Young, Trevor Douglas, and Allen G. Harmsen “Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function” American Journal of Pathology (2012) 181, 196-210
Temperature dependence of electron magnetic resonance spectra of iron oxide nanoparticles mineralized in Listeria innocua protein cages
Robert J. Usselman, Stephen E. Russek, Michael T. Klem, Mark A. Allen, Trevor Douglas, Mark Young,Yves U. Idzerda, and David J. Singel “Temperature dependence of electron magnetic resonance spectra of iron oxide nanoparticles mineralized in Listeria innocua protein cages” J. Applied Physics (2012) 112, 084701
Human Ferritin Cages for Imaging Vascular Macrophages
Masahiro Terashima, Masaki Uchida, Hisanori Kosuge, Philip S. Tsao, Mark J. Young, Steven M. Conolly, Trevor Douglas, and Michael V. McConnell “Human Ferritin Cages for Imaging Vascular Macrophages” Biomaterials (2011) 32, 1430 – 1437.
Structure and photoelectrochemistry of a virus capsid-TiO2 nanocomposite
Craig Jolley, Michael Klem, Richard Harrington, John Parise, and Trevor Douglas “Structure and photoelectrochemistry of a virus capsid-TiO2 nanocomposite”, Nanoscale (2011) 3, 1004 – 1007.
Monitoring Structural Transitions in Icosahedral Virus Protein Cages by Site Directed Spin Labeling
R.J. Ussellman, E.D. Walter, D. Willits, T. Douglas, M.J. Young, D.J. Singel “Monitoring Structural Transitions in Icosahedral Virus Protein Cages by Site Directed Spin Labeling” J Am Chem Soc (2011) 133, 4156–4159.
Protein Cage Nanoparticles Bearing the LyP-1 Peptide for Enhanced Imaging of Macrophage-Rich Vascular Lesions
Masaki Uchida, Hisanori Kosuge, Masahiro Terashima, Deborah A.Willits, Lars O. Liepold, Mark J. Young, Michael V. McConnell, and Trevor Douglas “Protein Cage Nanoparticles Bearing the LyP-1 Peptide for Enhanced Imaging of Macrophage-Rich Vascular Lesions”, ACS Nano (2011) 5, 2493–2502.
A water-soluble carbon nanotube network conjugated by nanoparticles with defined nanometer gaps
Mime Kobayashi, Bin Zheng, Shinya Kumagai, Yukiharu Uraoka, Trevor Douglas and Ichiro Yamashita “A water-soluble carbon nanotube network conjugated by nanoparticles with defined nanometer gaps” Chem Commun (2011) 47, 3475-3477.
Templated Assembly of Organic-Inorganic Materials Using the Core Shell Structure of the P22 Bacteriophage
C. Reichhardt, M. Uchida, A. O’Neil, R. Li, P. Prevelige, T. Douglas “Templated Assembly of Organic-Inorganic Materials Using the Core Shell Structure of the P22 Bacteriophage” Chem Commun (2011) 47, 6326-6328.
Development of a genetic system for the archaeal virus Sulfolobus turreted icosahedral virus
Jennifer Fulton Wirth, Jamie Snyder, Rebecca A. Hochstein, Alice C. Ortmann, Deborah A. Willits, Trevor Douglas, Mark Young “Development of a genetic system for the archaeal virus Sulfolobus turreted icosahedral virus” J. Virology (2011) 415, 6-11.
All in the packaging: Structural and electronic effects of nanoconfinement on metal oxide nanoparticles
C. Jolley, V. Pool, Y. Idzerda, T. Douglas “All in the packaging: Structural and electronic effects of nanoconfinement on metal oxide nanoparticles” Chem Mater (2011) 23, 3921–3929.
Biomimetic FePt nanoparticle synthesis within Pyrococcus furiosus ferritins and their layer-by-layer formation
Young Ji Kang, Masaki Uchida, Hyun-Hee Shin, Trevor Douglas, Sebyung Kang “Biomimetic FePt nanoparticle synthesis within Pyrococcus furiosus ferritins and their layer-by-layer formation”, Soft Matter (2011) 7, 11078-11081.
Genetically Programmed In Vivo Packaging of Protein Cargo and Its Controlled Release from Bacteriophage P22
A. O’Neil, C. Reichhardt, P. Prevelige, T. Douglas “Genetically Programmed In Vivo Packaging of Protein Cargo and Its Controlled Release from Bacteriophage P22” Angewandte Chemie (2011) 50, 7425-7428.
Orbital moment determination in (MnxFe1−x)3O4 nanoparticles
V.L. Pool, C. Jolley, T. Douglas, E.A. Arenholz, Y.U. Iderda “Orbital moment determination in (MnxFe1−x)3O4 nanoparticles” J. Applied Physics (2011) 109, 07B532.
Structure, dynamics, and solvation in a disordered metal-organic coordination polymer: a multiscale study
C. Jolley, J. Lucon, M. Uchida, C. Reichhardt, M. Vaughn, B. LaFrance, T. Douglas “Structure, dynamics, and solvation in a disordered metal-organic coordination polymer: a multiscale study” J Coordination Chem (2011) 64, 4301-4317.
Swelling and Softening of the CCMV Plant Virus Capsid in Response to pH Shifts
Bodo D. Wilts, Iwan A. T. Schaap, Mark J. Young, Trevor Douglas, Charles M. Knobler, Christoph F. Schmidt “Swelling and Softening of the CCMV Plant Virus Capsid in Response to pH Shifts” Biophysical Journal (2010) DOI: 10.1016/j.bpj.2009.12.3597
Biomimetic synthesis of photoactive α-Fe2O3 templated by the hyperthermophilic ferritin from Pyrococus furiosus
Michael Klem, Mark Young, Trevor Douglas “Biomimetic synthesis of photoactive α-Fe2O3 templated by the hyperthermophilic ferritin from Pyrococus furiosus” J. Mater. Chem. (2010) 20, 65-67.
Hydrogen Enhances Ni Ion Tolerance of Purple Sulfur Bacterium Thiocapsa roseopersicina
Oleg A. Zadvorny, Susan K. Brumfield, Trevor Douglas, Nikolay A. Zorin, and John W. Peters “Hydrogen Enhances Ni Ion Tolerance of Purple Sulfur Bacterium Thiocapsa roseopersicina” Environmental Science & Technology (2010) 44, 834-840.
A Click Chemistry Based Coordination Polymer Inside Small Heat Shock Protein
Janice Lucon, Md. J. Abedin, Masaki Uchida, Lars O. Liepold, Mark Young, Trevor Douglas “A Click Chemistry Based Coordination Polymer Inside Small Heat Shock Protein” Chem. Commun. (2010) 46, 264 – 266.
Some enzymes just need a space of their own
Sebyung Kang and Trevor Douglas “Some enzymes just need a space of their own” Science (2010) 327, 42-43.
The Ferritin Superfamily: Supramolecular Templates for Materials Synthesis
Masaki Uchida, Sebyung Kang, Courtney Reichhardt, Kevin Harlen, Trevor Douglas “The Ferritin Superfamily: Supramolecular Templates for Materials Synthesis” Biochimica et Biophysica Acta (2010), 1800, 834–845.
Protein Cage Nanoparticles as Secondary Building Units for the Synthesis of 3-Dimensional Coordination Polymers
Chris C. Broomell, Henrik Birkedal, Cristiano Luis Pinto De Oliveira, Jan S. Pedersen, Jan-Andre Gertenbach, Mark Young, and Trevor Douglas “Protein Cage Nanoparticles as Secondary Building Units for the Synthesis of 3-Dimensional Coordination Polymers” Soft Matter (2010) 6, 3167 – 3171.
Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm
Peter Suci, Sebyung Kang, Rudolf Gmur, Trevor Douglas and Mark Young “Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm” Antimicrobial Agents and Chemotherapy (2010), 54, 2489–2496.
Size and crystallinity in protein-templated inorganic nanoparticles
C. Jolley, M. Uchida, C. Reichhardt, R. Harrington, S. Kang, M. Klem, J. Parise, T. Douglas, “Size and crystallinity in protein-templated inorganic nanoparticles” Chem Mater (2010) 22, 4612-4618.
Site determination and magnetism of Mn doping in protein encapsulated iron oxide nanoparticles
V. Pool, M. Klem, C. Jolley, E.A. Arenholz, T. Douglas, M. Young, Y.U. Idzerda, “Site determination and magnetism of Mn doping in protein encapsulated iron oxide nanoparticles”, J. Applied Physics (2010) 107, 09B517.
Virus particles as active nanomaterials that can rapidly change their viscoelastic properties in response to dilute solutions
Vamseedhar Rayaprolu, Ben Manning, Trevor Douglas and Brian Bothner “Virus particles as active nanomaterials that can rapidly change their viscoelastic properties in response to dilute solutions”, Soft Matter (2010) 6, 5286-5288.
Two-component magnetic structure of iron oxide nanoparticles mineralized in Listeria innocua protein cages
R.J. Usselman, M. Klem, S. Russek, M. Young, T. Douglas, and Ron Goldfarb, “Two-component magnetic structure of iron oxide nanoparticles mineralized in Listeria innocua protein cages” J. Appl. Phys. (2010) 107, 114703.
A Network-Theoretical Approach to Understanding Interstellar Chemistry
Craig C. Jolley and Trevor Douglas “A Network-Theoretical Approach to Understanding Interstellar Chemistry” The Astrophysical Journal (2010) 722, 1921-1931.
Ion accumulation in a protein nanocage: finding noisy temporal sequences using a genetic algorithm
Craig C. Jolley, Trevor Douglas “Ion accumulation in a protein nanocage: finding noisy temporal sequences using a genetic algorithm”, Biophys J (2010) 99, 3385-3393.
Implementation of P22 Viral Capsids as Nanoplatforms
Sebyung Kang, Masaki Uchida, Alison O’Neil, Rui Li, Peter E. Prevelige, and Trevor Douglas “Implementation of P22 Viral Capsids as Nanoplatforms” Biomacromolecules (2010) 11, 2804-2809.
Bio-templated CdSe Nanoparticle Synthesis in a Cage Shaped Protein, Listeria-Dps, and Their Two Dimensional Ordered Array Self-Assembly
Mitsuhiro Okuda, Yoko Suzumoto, Kenji Iwahori, Sebyung Kang, Masaki Uchida, Trevor Douglas, and Ichiro Yamashita, “Bio-templated CdSe Nanoparticle Synthesis in a Cage Shaped Protein, Listeria-Dps, and Their Two Dimensional Ordered Array Self-Assembly”, Chem. Commun. (2010) 46, 8797-8799.
Determination of Anisotropy Constants of Protein Encapsulated Iron Oxide Nanoparticles by Electron
H. Li, M.T Klem, K. B. Sebby, D.J. Singel, M. Young, T. Douglas, YU. Idzerda “Determination of Anisotropy Constants of Protein Encapsulated Iron Oxide Nanoparticles by Electron” J. of Magnetism and Magnetic Materials (2009) 321, 175-180.(2010) 46, 8797-8799.
Prophylactic Efficacy of Intranasally Administered HSP Nanoparticles for Treating a Lethal SARS-CoV Infection in BALB/c Mice
Dale Barnard, James Wiley, Miles Wandersee, Yohichi Kumaki, Mark Young, Trevor Douglas, Allan Harmsen “Prophylactic Efficacy of Intranasally Administered HSP Nanoparticles for Treating a Lethal SARS-CoV Infection in BALB/c Mice” Antiviral Research (2009) DOI: 10.1016/j.antiviral.2009.02.059
Correct Charge State Assignment of Native Electrospray Spectra of Protein Complexes
Lars O. Liepold, Luke M. Oltrogge, Peter Suci, Mark J. Young, Trevor Douglas “Correct Charge State Assignment of Native Electrospray Spectra of Protein Complexes” J. Amer. Society for Mass Spec. (2009) 20 435-442.
Synergistic Effects of Mutations and Nanoparticle Templating in the Self-Assembly Of Cowpea Chlorotic Mottle Virus Capsids
S.E. Aniagyei, C.J. Kennedy, B. Stein, D.A. Willits, T. Douglas, M.J. Young, M. De, V. M. Rotello, D. Srisathiyanarayanan, C. C. Kao, and B. Dragnea, “Synergistic Effects of Mutations and Nanoparticle Templating in the Self-Assembly Of Cowpea Chlorotic Mottle Virus Capsids”, Nano Letters (2009) 9, 393-398.
Genetics, biochemistry and structure of the archaeal virus STIV
J. Fulton, B.B. Bothner, M. Lawrence, J.E. Johnson, T. Douglas, M. Young “Genetics, biochemistry and structure of the archaeal virus STIV” Biochemical Society Transactions (2009) 37, 114-117.
Synthesis of a crosslinked branched polymer network in the interior of a protein cage
Md. J. Abedin, L.O. Liepold, P. Suci, M. Young, T. Douglas “Synthesis of a crosslinked branched polymer network in the interior of a protein cage” J. Amer. Chem. Soc. (2009) 131, 4346-4354.
Site Determination of Zn Doping in Protein Encapsulated ZnxFe3-xO4 Nanoparticles
V. Pool, M. Klem, J. Holroyd, T. Harris, E. Arenholz, T. Douglas, M. Young, and Y.U. Idzerda “Site Determination of Zn Doping in Protein Encapsulated ZnxFe3-xO4 Nanoparticles” J. Appl. Phys (2009) 105, 07B515.
In-Plane Ordering of Genetically Engineered Viral Protein Cage
M. Klem, P. Suci, D. Britt, M. Young, T. Douglas “In-Plane Ordering of Genetically Engineered Viral Protein Cage” Journal of Adhesion (2009) 85, 69-77.
Structural and Functional Studies of Archaeal Viruses
C. Martin Lawrence, Smita Menon, Brian J. Eilers, Brian Bothner, Trevor Douglas, and Mark J. Young “Structural and Functional Studies of Archaeal Viruses” J. Biological Chem. (2009) 284, 12599–12603.
Particle assembly and ultrastructural features associated with replication of the lytic archaeal virus Sulfolobus turreted icosahedral virus (STIV)
S. Brumfield, A. Ortmann, V. Ruigrok, P. Suci, T. Douglas, M. Young “Particle assembly and ultrastructural features associated with replication of the lytic archaeal virus Sulfolobus turreted icosahedral virus (STIV)” J. Virology (2009) 83, 5964–5970.
From Metal Binding to Nanoparticle Formation; Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry
Sebyung Kang, Craig C. Jolley, Lars O. Liepold, Mark Young, and Trevor Douglas, “From Metal Binding to Nanoparticle Formation; Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry”, Angew. Chemie. (2009) 48, 4772-4776.
Janus-like Protein Cages; Spatially Controlled Dual-functional Surface Modifications of Protein Cages
Sebyung Kang, Peter A. Suci, Chris C. Broomell, Ichiro Yamashita, Mark Young, and Trevor Douglas “Janus-like Protein Cages; Spatially Controlled Dual-functional Surface Modifications of Protein Cages” Nano Letters (2009), 6, 2360-2366.
Photosensitizer Efficiency in Genetically Modified Protein Cage Architectures
Z. Varpness, P. Suci, D. Ensign, M. Young, T. Douglas “Photosensitizer Efficiency in Genetically Modified Protein Cage Architectures” Chem Commun (2009) 3726-3728.
A streptavidin-protein cage Janus particle for polarized targeting and modular functionalization
P. Suci, S. Kang, M. Young, T. Douglas “A streptavidin-protein cage Janus particle for polarized targeting and modular functionalization” J. Amer. Chem. Soc. (2009) 131, 9164–9165.
Targeted Protein Cage Nanoparticles Detects Macrophages Accumulation in Mouse Atherosclerosis using Fluorescence Imaging
Masahiro Terashima, Masaki Uchida, Hisanori Kosuge, Mark Young, Trevor Douglas and Michael McConnell, “Targeted Protein Cage Nanoparticles Detects Macrophages Accumulation in Mouse Atherosclerosis using Fluorescence Imaging” Circulation 118, S554-S555, 2009.
Something old, something new, something borrowed; how the thermoacidophilic archeaon Sulfolobus solfataricus responds to oxidative stress
W. S. Maaty, B. Wiedenheft, J. Heinemann, P. Tarlykov, J. Robison-Cox, N. Schaff, J. Valenzuela, A. Dougherty, P. Blum, T. Douglas, M. J. Young and B. Bothner “Something old, something new, something borrowed; how the thermoacidophilic archeaon Sulfolobus solfataricus responds to oxidative stress” PLOS One (2009) 4, e6964.
Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses
James A. Wiley, Laura E. Richert, Steve D. Swain, Ann Harmsen, Dale L. Barnard, Troy D. Randall, Mark Jutila, Trevor Douglas, Chris Broomell, Mark Young, Allen Harmsen. “Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses” PLOS One (2009) 4, e7142.
Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties
Lars O. Liepold, Md Joynal Abedin, Emily D. Buckhouse, Joseph A. Frank, Mark J. Young, Trevor Douglas “Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties” Nano Letters (2009) 9, 4520–4526.
Expanding the Temperature Range of Biomimetic Synthesis Using a Ferritin from the Hyperthermophile Pyrococcus furiosus
M. Parker, B. Ramsay, M. Allen, M. Klem, M. Young, T. Douglas “Expanding the Temperature Range of Biomimetic Synthesis Using a Ferritin from the Hyperthermophile Pyrococcus furiosus” Chem. Mater. (2008) 20, 1541-1547.
Photochemical Mineralization of Europium, Titanium and Iron Oxyhydroxide Nanoparticles in the Ferritin Protein Cage
M. Klem, J. Mosolf, M. Young, T. Douglas “Photochemical Mineralization of Europium, Titanium, and Iron Oxyhydroxide nanoparticles in the Ferritin Protein Cage” Inorganic Chemistry (2008) 47, 2237-2239.
Transcriptome analysis of infection of the archaeon Sulfolobus solfataricus with STIV
Alice C. Ortmann, Susan K. Brumfield, Jasper Walther, Kathleen McInnerney, Stan J. J. Brouns, Harmen J. G. van de Werken, Brian Bothner, Trevor Douglas, John van de Oost, and Mark J. Young “Transcriptome analysis of infection of the archaeon Sulfolobus solfataricus with STIV” J. Virology (2008) 82, 4874-4883.
H2 catalysis by Pt nanoparticles in Ferritin
Z. Varpness, C. Shoopman, J. Peters, M. Young, T. Douglas “H2 catalysis by Pt nanoparticles in Ferritin” ACS Symposium Series (2008) 986, 263- 272.
Biomimetic Synthesis of β-TiO2 Inside a Viral Capsid
M. Klem, M. Young, T. Douglas “Biomimetic Synthesis of β-TiO2 Inside a Viral Capsid” J. Materials Chem (2008) 18, 3821-3823.
Plant Viruses as Biotemplates for Materials and Their Use in Nanotechnology
M. Young, D. Willits, M. Uchida, T. Douglas “Plant Viruses as Biotemplates for Materials and Their Use in Nanotechnology” Annual Reviews in Phytopathology (2008) 46, 361-368.
Monitoring Biomimetic Platinum Nanocluster Formation using Non-covalent Mass Spectrometry and Cluster Dependent H2 Production
Sebyung Kang, Janice Lucon, Zachary B. Varpness, Lars Liepold, Masaki Uchida, Debbie Willits, Mark J. Young, and Trevor Douglas “Monitoring Biomimetic Platinum Nanocluster Formation using Non-covalent Mass Spectrometry and Cluster Dependent H2 Production” Angewandte Chemie (2008) 47, 7845 – 7848.
A Library of Protein Cage Architectures as Nanomaterials
M.L. Flenniken, L. Liepold, S. Kang, M. Uchida, M.J. Young, T. Douglas “A Library of Protein Cage Architectures as Nanomaterials” Current Opinion in Microbiology and Immunology (2008) 327, 71-94.
Signal amplification using nanoplatform cluster formation
P. Suci, M. Klem, M. Young, T. Douglas “Signal amplification using nanoplatform cluster formation” Soft Matter (2008), 4, 2519 – 2523.
A Human Ferritin Iron Oxide Nano-composite Magnetic Resonance Contrast Agent
M. Uchida, M. Terashima, C. H. Cunningham, Y. Suzuki, D.A.Willits, A. F. Willis, P. C. Yang, P. S. Tsao, M. V. McConnell, M. J. Young and T. Douglas. “A Human Ferritin Iron Oxide Nano-composite Magnetic Resonance Contrast Agent” Magnetic Resonance in Medicine (2008) 60, 1073-1081.
Controlled Assembly of Bifunctional Chimeric Protein Cages and Composition Analysis using Non-covalent Mass Spectrometry
Sebyung Kang, Luke M. Oltrogge, Chris C. Broomell, Lars O. Liepold, Peter E. Prevelige, Mark Young, and Trevor Douglas “Controlled Assembly of Bifunctional Chimeric Protein Cages and Composition Analysis using Non-covalent Mass Spectrometry” J. Amer. Chem. Soc. (2008) 130, 16527-16529.
Intra-cellular Distribution of Macrophage Targeting Ferritin Iron Oxide Nano-composite
Masaki Uchida, Deborah A. Willits, Karin Muller, Ann F. Willis, Mark J. Young, Alexandra E. Porter and Trevor Douglas “Intra-cellular Distribution of Macrophage Targeting Ferritin Iron Oxide Nano-composite” Advanced Materials (2008) 20, 1-5.
Virus movement maintains local virus population diversity
J.C. Snyder, B. Wiedenheft, M. Lavin, F. Roberto, J. Spuhler, A.C. Ortmann, T. Douglas, M. Young “Virus movement maintains local virus population diversity“ Proceedings of the National Academy of Sciences (2007) 104, 19102-19107.
Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo
C. R. Kaiser, M. Flenniken, E. Gillitzer, A. G.Harmsen, A. L.Harmsen, M. Jutila, T.Douglas, and M. J. Young “Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo.” Int J Nanomedicine (2007) 2, 715 – 731.
Targeting and Photodynamic Killing of a Microbial Pathogen Using Protein Cage Architectures Functionalized with a Photosensitizer
P.A. Suci, Z. Varpness, E. Gillitzer, T. Douglas, M. Young “Targeting and Photodynamic Killing of a Microbial Pathogen Using Protein Cage Architectures Functionalized with a Photosensitizer “ Langmuir (2007) 23, 12280 – 12286.
High-density targeting of a viral multifunctional nanoplatform to a pathogenic, biofilm-forming bacterium
P. A. Suci, D. L. Berglund, L. Liepold, S. Brumfield, B. Pitts, W. Davison, L. Oltrogge, K. O. Hoyt, S. Codd, P. S. Stewart, M. Young and T. Douglas “High-density targeting of a viral multifunctional nanoplatform to a pathogenic, biofilm-forming bacterium.” Chemistry & Biology (2007) 14, 387-398.
Viral Capsids as MRI contrast agents
L.O. Liepold, S. Anderson, D. Willits, L. Oltrogge, J.A. Frank, T. Douglas, and M. Young “Viral Capsids as MRI contrast agents” Magnetic Resonance in Medicine (2007) 58, 871-880.
Biological Containers: Protein Cages as Multifunctional Nanoplatforms
M. Uchida, M.T. Klem, M Flenniken, M. Allen, Z. Varpness, E. Gillitzer, P. Suci, M. Young and T. Douglas “Biological Containers: Protein Cages as Multifunctional Nanoplatforms” Advanced Materials (2007) 19, 1025-1042.
Bioprospecting in high temperature environments; application of thermostable protein cages
B. Wiedenheft, M. Flenniken, M.A.Allen, M. Young, T. Douglas “Bioprospecting in high temperature environments; application of thermostable protein cages“ Soft Matter (2007) 3, 1019-1098.
Synthetic control over magnetic moment and exchange bias in all-oxide materials encapsulated within a spherical protein cage
M. T. Klem, D. A. Resnick, K. Gilmore, M. Young, Y. U. Idzerda and T. Douglas “Synthetic control over magnetic moment and exchange bias in all-oxide materials encapsulated within a spherical protein cage” J Am Chem Soc (2007) 129: 197-201.
Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles
M. Uchida, M. L. Flenniken, M. Allen, D. A. Willits, B. E. Crowley, S. Brumfield, A. F. Willis, L. Jackiw, M. Jutila, M. J. Young and T. Douglas “Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles.” J Am Chem Soc (2006) 128: 16626-33.
Assembly of multilayer layer films incorporating a viral protein cage architecture
P. Suci, M. Klem, T. Douglas, M. Young “Assembly of multilayer layer films incorporating a viral protein cage architecture” Langmuir (2006) 22, 8891-8896.
Controlled Ligand Display on a Symmetrical Protein-Cage Architecture Through Mixed Assembly
E. Gillitzer, P. Suci, M. Young, T. Douglas “Controlled Ligand Display on a Symmetrical Protein-Cage Architecture Through Mixed Assembly” Small (2006) 2, 962-966.
Structure of the DPS-like Protein from Sulfolobus solfataricus Reveals a Bacterioferritin-Like Dimetal Binding Site within a DPS-Like Dodecameric Assembly
G.H. Gauss, P. Benas, B. Wiedenheft, M. Young, T. Douglas, C. M. Lawrence “Structure of the DPS-Like Protein from Sulfolobus solfataricus Reveals a Bacterioferritin-Like Dimetal Binding Site within a DPS-Like Dodecameric Assembly” Biochemistry (2006) 45, 10815 – 10827.
Characterization of the Archaeal Thermophile Sulfolobus Turreted Icosahedral Virus Validates an Evolutionary Link among Double-Stranded DNA Viruses from All Domains of Life
W.S.A. Maaty, A. Ortmann, M. Dlakic, K. Schulstad, J. Hilmer, L.O. Liepold, B. Wiedenheft, R. Khayat, T. Douglas, M. Young, B. Bothner “Characterization of the Archaeal Thermophile Sulfolobus Turreted Icosahedral Virus Validates an Evolutionary Link among Double-Stranded DNA Viruses from All Domains of Life” J. Virology (2006) 80, 7625-7635.
Hot crenarchaeal viruses reveal deep evolutionary connections
A. Ortmann, B. Wiedenheft, T. Douglas, M. Young “Hot crenarchaeal viruses reveal deep evolutionary connections“ Nature Reviews Microbiology (2006) 4, 520-528.
Viruses: Making Friends With Old Foes
T. Douglas, M. Young “Viruses: Making Friends With Old Foes” Science (2006) 312, 873-875.
Brain Engraftment and Therapeutic Potential of Stem/Progenitor Cells Derived from Mouse Skin
P. Tunici, J. W.M. Bulte, M. G. Bruzzone, P. L. Poliani, L. Cajola, M. Grisoli, T. Douglas, G. Finocchiaro, “Brain Engraftment and Therapeutic Potential of Stem/Progenitor Cells Derived From Mouse Skin ” J Gene Med (2006) 8, 506-513.
Magnetic properties of Co3O4 nanoparticles mineralized in Listeria innocua Dps
D. A. Resnick, K. Gilmore, Y. U. Idzerda, M. T. Klem, M. Allen, E. Arenholz, T. Douglas, M. Young “Magnetic properties of Co3O4 nanoparticles mineralized in Listeria innocua Dps” J. Appl. Physics (2006) 99, 08Q501.
Dps-like protein from the hyperthermophilic archaeaon Pyrococcus furiosis
B. Ramsey, B. Wiedenheft, M. Allen, G. H. Gauss, C. M. Lawrence, M. Young, T. Douglas “Dps-like protein from the hyperthermophilic archaeaon Pyrococcus furiosis” J. Inorganic Biochemistry (2006) 100, 1061-1068.
A radical solution for the biosynthesis of the H-cluster of hydrogenase
J.W. Peters, R.K. Szilagyi, A. Naumov, and T. Douglas “A radical solution for the biosynthesis of the H-cluster of hydrogenase” FEBS Lett (2006) 580, 363-367.
Melanoma and Lymphocyte Targeting Incorporated into a Heat Shock Protein Cage Architecture
M.L. Flenniken, D.A. Willits, A.L. Harmsen, L.O. Liepold, A.G. Harmsen, M.J. Young, T. Douglas “Melanoma and Lymphocyte Targeting Incorporated into a Heat Shock Protein Cage Architecture” Chemistry and Biology (2006) 13, 161-170.
Immobilization of Active Hydrogenases by Encapsulation in Polymeric Porous Gels
T.E. Elgren, O.A. Zadvorny, E. Brecht, T. Douglas, N.A. Zorin, M.J. Maroney, J.W. Peters “Immobilization of Active Hydrogenases by Encapsulation in Polymeric Porous Gels” Nano Letters (2005) 5, 2085-2087.
Biomimetic synthesis of a H2 catalyst using a protein cage architecture
Z. Varpness, J. Peters, M. Young, T. Douglas “Biomimetic synthesis of a H2 catalyst using a protein cage architecture” Nano Letters (2005), 5, 2306-2309.
Structural Transitions in Cowpea Chlorotic Mottle Virus (CCMV)
L.O. Liepold, J. Revis, M.A. Allen, L. Oltrogge, M. Young, T. Douglas “Structural Transitions in Cowpea Chlorotic Mottle Virus (CCMV)” Physical Biology (2005) 2, 166 – 172.
Paramagnetic Viral Nanoparticles as Potential High-Relaxivity Magnetic Resonance Contrast Agents
M. A. Allen, J.W.M. Bulte, L.O. Liepold, G. Basu, H.A. Zywicke, J.A. Frank, M. Young, T. Douglas “Paramagnetic Viral Nanoparticles as Potential High-Relaxivity Magnetic Resonance Contrast Agents” Magnetic Resonance in Medicine (2005), 54, 807-812.
Charge Development on Ferritin: An Electrokinetic study of a Protein Containing a Ferrihydrite Nanoparticle
M.A.Allen, T. Douglas, D. Nest, M. Schoonen, D.R. Strongin “Charge Development on Ferritin: An Electrokinetic study of a Protein Containing a Ferrihydrite Nanoparticle” Nanotechnology and the Environment ACS Symposium Series (2005) 890, 226-229.
A Bioengineering Approach to the Production of Metal and Metal Oxide Nanoparticles
H-A. Hosein, D.R. Strongin, T. Douglas, K. Rosso “A Bioengineering Approach to the Production of Metal and Metal Oxide Nanoparticles” Nanotechnology and the Environment ACS Symposium Series (2005) 890, 230-237.
Electron Magnetic Resonance of Iron Oxide Nanoparticles Mineralized in Protein Cages
R.J.Usselman, M.T. Klem, M. Allen, T. Douglas, D.J. Singel , D. Willits, M. Young, K. Gilmore, Y Idzerda. “Electron Magnetic Resonance of Iron Oxide Nanoparticles Mineralized in Protein Cages” J. Appl. Physics (2005) 97, 10M523.
Surface Contribution to the Anisotropy Energy of Spherical Magnetite Particles
K. Gilmore,Y.U. Idzerda, M.T. Klem, M.Allen, and T.Douglas, M.Young “Surface Contribution to the Anisotropy Energy of Spherical Magnetite Particles” J. Appl. Physics (2005) 97, 10B301.
Biomimetic Magnetic Nanoparticles
M.T. Klem, M. Young, T. Douglas “Biomimetic Magnetic Nanoparticles” Materials Today (2005) 8, 28-37.
Archaeal Viruses from Yellowstone’s High Temperature Environments
M. Young, J. Snyder, B. Wiedenheft, J. Spuhler, F. Roberto, and T. Douglas “Archaeal Viruses from Yellowstone’s High Temperature Environments” in Geothermal Biology and Geochemistry in Yellowstone National Park, Thermal Biology Institute, 2005.
Selective Attachment and Release of a Chemotherapeutic Agent from the Interior of a Protein Cage Architecture
M.L. Flenniken, L.O. Liepold, B.E. Crowley, D.A. Willits, M.J. Young, T. Douglas “Selective Attachment and Release of a Chemotherapeutic Agent from the Interior of a Protein Cage Architecture” Chemical Communications (2005), 447-449.
Influence of electrostatic interactions on surface adsorption of a viral protein cage
P.A.Suci, M.T. Klem, T. Douglas, and M.J. Young “Influence of electrostatic interactions on surface adsorption of a viral protein cage” Langmuir (2005) 21, 8686-8693.
Bio-Inspired Synthesis of Protein Encapsulated CoPt Nanoparticles
M.T. Klem, D.A. Willits, D.J. Solis, A.M. Belcher, M. Young, and T. Douglas “Bio-Inspired Synthesis of Protein Encapsulated CoPt Nanoparticles” Advanced Functional Materials (2005) 15, 1489-1494.
An archaeal antioxidant: Characterization of a Dps-like protein from Sulfolobus solfataricus
B. Wiedenheft, D. Willits, J. Mosolf, M.Yeager, K. Dryden, M. Young and T. Douglas “An archaeal antioxidant: Characterization of a Dps-like protein from Sulfolobus solfataricus” Proceedings of the National Academy of Sciences (2005) 102, 10551-10556.
Self-assembling protein cage systems and applications in nanotechnology
T. Douglas, M. Allen, M. Young “Self-assembling protein cage systems and applications in nanotechnology”, Biopolymers Online (2005) 8, 405-426.
Effects of culturing on the population structure of a hyperthermophilic virus
J. Snyder, J.C. Spuhler, B. Wiedenheft, F. Roberto, T. Douglas, M. Young “Effects of culturing on the population structure of a hyperthermophilic virus” Micobial Ecology (2004) 48, 561-566.
Microbe Manufacturers of Semiconductors
M. Flenniken, M. Allen, T. Douglas “Microbe Manufacturers of Semiconductors” Chemistry & Biology (2004) 11, 1478-1480.
Modeling the magnetic behavior of g-Fe2O3 nanoparticles mineralized in ferritin
D. Resnick, K. Gilmore, Y.U. Idzerda, M. Klem, E. Smith, T. Douglas “Modeling the magnetic behavior of g-Fe2O3 nanoparticles mineralized in ferritin”, J. Applied Physics (2004) 95, 7127-7129.
Iron and Cobalt Oxide and Metallic Nanoparticles Prepared from Ferritin
H-A. Hosein, D.A. Strongin, M.A. Allen, T. Douglas ” Iron and Cobalt Oxide and Metallic Nanoparticles Prepared from Ferritin” Langmuir (2004) 20, 10283-10287.
Comparative genomic analysis of hyperthermophilic Archaeal fuselloviridae viruses
B. Wiedenheft, K. Stedman, F. Roberto, D. Willits, A.-K. Gleske, L. Zoeller, J. Snyder, T. Douglas and M.Young, “Comparative genomic analysis of hyperthermophilic Archaeal fuselloviridae viruses” J. Virology (2004) 78, 1954-1961.
Heterologous expression of the modified coat protein of Cowpea chlorotic mottle bromovirus results in the assembly of protein cages with altered architectures and function
S. Brumfield, D. Willits, L. Tang, J.E. Johnson, T. Douglas, and M.Young, “Heterologous expression of the modified coat protein on Cowpea chlorotic mottle bromovirus results in the assembly of protein cages with altered architectures and function”, J. General Virology (2004) 85, 1049-1053.
Photocatalytic Synthesis of Copper Colloids From Cu(II) by the Ferrihydrite Core of Ferritin
D. Ensign, M. Young, T. Douglas, “Photocatalytic Synthesis of Copper Colloids From Cu(II) by the Ferrihydrite Core of Ferritin” Inorganic Chemistry (2004), 43, 3441-3446.
The structure of a thermophilic archaeal virus shows a double-stranded DNA viral capsid type spans all domains of life
G. Rice, L. Tang, K. Stedman, F. Roberto, J. Spuhler, Eric Gillitzer, J.E. Johnson, T. Douglas, and M. Young “The structure of a thermophilic archaeal virus shows a double-stranded DNA viral capsid type spans all domains of life” Proceedings of the National Academy of Sciences (2004), 101, 7716-7720.
In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord
I-H. Lee, J.W.M. Bulte, P. Schweinhardt, T. Douglas, A. Trifunovski, C. Hofstetter, L. Olson , C. Spenger. “In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord”, Experimental Neurology (2004), 187, 509-516.
Noninvasive Monitoring of Stem Cell Transfer for Muscle Disorders
G.A. Walter, K.S. Cahill, J.Huard, H. Feng, T. Douglas, H.L.Sweeney, and J.W.M. Bulte “Noninvasive Monitoring of Stem Cell Transfer for Muscle Disorders”Magnetic Resonance in Medicine (2004), 51, 273-277.
Preparation of Magnetically Labeled Cells for Cell Tracking by Magnetic Resonance Imaging
J.W.M. Bulte, A.S. Arbab, T. Douglas, J.A. Frank “Preparation of Magnetically Labeled Cells for Cell Tracking by Magnetic Resonance Imaging” Methods in Enzymology (2004) 386, 275-299.
Effects of the Cowpea chlorotic mottle bromovirus b-hexamer structure on virion assembly
D. Willits, X. Zhao, N. Olson, T.S. Baker, A. Zlotnick, J.E. Johnson, T. Douglas, and M.J. Young “Effects of the Cowpea chlorotic mottle bromovirus b-hexamer structure on virion assembly” Virology, (2003) 306, 280-288.
A Bright Bio-inspired Future
T. Douglas “A Bright Bio-inspired Future”, Science (2003), 299, 1192-1193.
MR Microscopy of Magnetically Labeled Neurospheres Transplanted Into the Lewis EAE Rat Brain
J.W.M. Bulte, B.R. Miller, R. Mizachi-Kol, O. Einstein, E. Reinhartz, H.A. Zywicke, T. Douglas, and J.A. Franks “MR Microscopy of Magnetically Labeled Neurospheres Transplanted Into the Lewis EAE Rat Brain” Magnetic Resonance in Medicine (2003) 50, 201-205.
Metal binding to Cowpea Chlorotic mottle Virus using Tb(III) Fluorescence
T. Douglas, M. Allen, M. Young “Self-assembling protein cage systems and applications in nanotechnology”, Biopolymers (2003) 8, 405-426.
Constrained Synthesis of Cobalt Oxide Nano-Materials In the 12-subunit Protein Cage From Listeria innocua
M.A. Allen, D. Willits, M. Young, T. Douglas “Constrained Synthesis of Cobalt Oxide Nano-Materials In the 12-subunit Protein Cage From Listeria innocua” Inorganic Chemistry (2003) 42, 6300-6305.
2-D Array Formation of Genetically Engineered Viral Cages on Au Surfaces and Imaging by Atomic Force Microscopy
M. T. Klem, D. A. Willits, M. J. Young, and T. Douglas “2-D Array Formation of Genetically Engineered Viral Cages on Au Surfaces and Imaging by Atomic Force Microscopy ” J. American Chemical Society (2003) 125, 1056-1057
The Small Heat Shock Protein from Methanococcus jannaschii is a Versatile Nano-scale Platform for Genetic and Chemical Modification
M.L. Flenniken, D.A. Willits, S. Brumfield, M.J. Young, and T. Douglas “The Small Heat Shock Protein from Methanococcus jannaschii is a Versatile Nano-scale Platform for Genetic and Chemical Modification” Nano Letters (2003) 3, 1573-1576.
Monitoring Stem Cell Therapy in Vivo Using Magnetodendrimers as a New Class of Cellular MR Contrast Agents
Jeff W. M. Bulte, Trevor Douglas, Brian Witwer, Su-Chun Zhang, Bobbi K. Lewis, Peter van Gelderen, Holly Zywicke “Monitoring Stem Cell Therapy in Vivo Using Magnetodendrimers as a New Class of Cellular MR Contrast Agents” Academic Radiology (2002) DOI: 10.1016/S1076-6332(03)80221-0
Chemical Modification of a Viral Cage for Multivalent Presentation
E. Gillitzer, D. Willits, M. Young, and T. Douglas “Chemical Modification of a Viral Cage for Multivalent Presentation” Chemical Communications (2002) 2390-2391.
MR microscopy of magnetodendrimer uptake in single cells
P. D. Majors, E. J. Ackerman, R. A. Wind, T. Douglas, and J. W. M. Bulte, Proc. Intl. Soc. Magn. Reson. Med. (2002), 10, 2571
Photochemical reactivity of ferritin for Cr(VI) reduction
Ivan Kim, H-A. Hosein, D.A.Strongin, T.Douglas, “Photochemical reactivity of ferritin for Cr(VI) reduction”, Chemistry of Materials (2002), 14, 4874-4879.
Protein Cage Constrained Synthesis of Ferrimagnetic Iron Oxide Nanoparticles
M. Allen, D. Willits, J. Mosolf, M. Young, and T. Douglas, “Protein Cage Constrained Synthesis of Ferrimagnetic Iron Oxide Nanoparticles” Advanced Materials (2002) 14, 1562-1565.
Protein Engineering of a Viral Cage for Constrained Nano-Materials Synthesis
T. Douglas, E. Strable, D. Willits, A. Aitouchen, M. Libera, and M. Young, “Protein Engineering of a Viral Cage for Constrained Nano-Materials Synthesis” Advanced Materials (2002), 14, 415-418.
Ordered association of tobacco mosaic virus in the presence of divalent metal ions
Aleksey Nedoluzhko, Trevor Douglas “Ordered association of tobacco mosaic virus in the presence of divalent metal ions” Journal of Inorganic Biochemistry (2001) DOI: 10.1016/s0162-0134(01)00174-x
Magnetodendrimers as a New Class of MR Contrast Agents for Universal, Non-Specific Magnetic Labeling and In Vivo Tracking of Mammalian (Stem) Cells
J.W.M. Bulte, T. Douglas, B. Witwer, S-C. Zhang, E. Strable, B.K. Lewis, H. Zywicke, B. Miller, P. van Gelderen, B.M. Moskowitz, I.D. Duncan, and J.A. Franks “Magnetodendrimers as a New Class of MR Contrast Agents for Universal, Non-Specific Magnetic Labeling and In Vivo Tracking of Mammalian (Stem) Cells” Nature Biotechnology (2001), 19, 1141.
Biomimetic Materials Chemistry
A. Nedoluzhko, T. Douglas “Biomimetic Materials Chemistry” in Focus on Biotechnology (vol 7), M de Cuyper, J.W.M. Bulte (eds.), Kluwer Academic Press, Dordrecht, 2001.
Magnetodendrimers: Synthesis of Soluble Nanophase Mineral-Organic Composites
E. Strable, J.W.M Bulte,.B.M. Moskowitz, K. Vivekanandan, M. Allen, T. Douglas “Magnetodendrimers: Synthesis of Soluble Nanophase Mineral-Organic Composites” Chemistry of Materials (2001), 13, 2201-2209.
Dynamic Relaxometry: Application to Iron Uptake by Ferritin
V. Herynek, J.W.M. Bulte, T. Douglas, R.A. Brooks “Dynamic Relaxometry: Application to Iron Uptake by Ferritin” Journal of Biological Inorganic Chemistry (2000) 5, 51-56.
Nanophase Cobalt Oxyhydroxide Mineral Synthesized within the Protein Cage of Ferritin
T. Douglas and V. Stark “Nanophase Cobalt Oxyhydroxide Mineral Synthesized within the Protein Cage of Ferritin” Inorganic Chemistry (2000) 39, 1828-1830.
Virus Particles as Templates for Materials Synthesis
Trevor Douglas, Mark Young “Virus Particles as Templates for Materials Synthesis” Advanced Materials (1999) DOI: 10.1002/(SICI)1521-4095(199906)11:8<679::AID-ADMA679>3.0.CO;2-J
Inorganic-Organic Nanotube Composites From Template Mineralization of Tobacco Mosaic Virus
W. Shenton, T. Douglas, M. Young, G. Stubbs, S. Mann “Inorganic-Organic Nanotube Composites From Template Mineralization of Tobacco Mosaic Virus ” Advanced Materials (1999), 11, 253-256.
Self-Assembled Single-Chain Oligo(p-Phenylene) Amphiphiles: Reversed Micelles, Vesicles, and Gels
V. Sidorov, T. Douglas, S.M. Dzekunov, D. Abdallah, B. Ghebremariam, P.D. Roepe and Stefan Matile “Self-Assembled Single-Chain Oligo(p-Phenylene) Amphiphiles: Reversed Micelles, Vesicles, and Gels” Chemical Communications (1999), 1429-1430.
Synthesis and Characterisation of Hydrophobic Ferritin Proteins
K. K. W. Wong, H. Colfen, N. T. Whilton, T. Douglas, and S. Mann, ” Synthesis and Characterisation of Hydrophobic Ferritin Proteins” J. Inorganic Biochemisrty(1999) 76, 187-195.
Biomimetic Synthesis and Characterization of Magnetic Proteins (Magnetoferritin)
K.K.W. Wong, T. Douglas, S. Gider, D.D. Awschalom and S. Mann “Biomimetic Synthesis and Characterization of Magnetic Proteins (Magnetoferritin)” Chemistry of Materials, (1998), 10, 279-285.
Hydrophobic Proteins: Synthesis and Characterisation of Organic-Soluble Alkylated Ferritins
K. K. W. Wong, N. T. Whilton, H. Colfen, T. Douglas, and S. Mann, “Hydrophobic Proteins: Synthesis and Characterisation of Organic-Soluble Alkylated Ferritins,” Chemical Communications (1998), 1621-1622.
Calculated Electrostatic Gradients in Recombinant Human H-Chain Ferritin
T. Douglas, D.R. Ripoll, “Calculated Electrostatic Gradients in Recombinant Human H-Chain Ferritin” Protein Science (1998), 7, 1083-1091.
Host Guest Encapsulation of Materials by Assembled Virus Protein Cages
T. Douglas, M. Young, ” Host Guest Encapsulation of Materials by Assembled Virus Protein Cages” Nature (1998) 393, 152-155.
Determination of the Preexponential Frequency Factor for Superparamagnetic Maghemite Particles in Magnetoferritin
B.M. Moskowitz, R.B. Frankel, S.A. Walton, D.P.E. Dickson, K.K.W. Wong, T. Douglas, S. Mann, “Determination of the Preexponential Frequency Factor for Superparamagnetic Maghemite Particles in Magnetoferritin” J. Geophys. Res., (1997), 102, 22671-22680.
Immunomagnetic Isolation of Magnetoferritin-labeled Cells in a Modified Ferrograph
M. Zborowski, C. B. Fuh, R. Green, N. J. Baldwin, S. Reddy, T. Douglas, S. Mann, J.J. Chalmers, “Immunomagnetic Isolation of Magnetoferritin-labeled Cells in a Modified Ferrograph” Cytometry (1996) 24, 251-259.
Classical and Quantum Magnetism in Synthetic Ferritin Proteins
S. Gider, D.D. Awschalom, T. Douglas, K. Wong, S. Mann, G. Cain, “Classical and Quantum Magnetism in Synthetic Ferritin Proteins” J. Appl. Phys. (1996) 79, 5324-5326.
Inorganic-Protein Interactions in the Synthesis of a Ferrimagnetic Nanocomposite
T. Douglas, J.W.M. Bulte, Q.A. Pankhurst, D.P.E. Dickson, B.M. Moskowitz, R.B. Frankel, S. Mann, “Inorganic-Protein Interactions in the Synthesis of a Ferrimagnetic Nanocomposite”, in Hybrid Organic-Inorganic Composites, J.E. Mark, P. Bianconi (eds), American Chemical Society, Washington DC (1995).
Reconstitution of Manganese Oxide Cores in Horse Spleen and Recombinant Ferritins
F.C. Meldrum, T. Douglas, S. Levi, P. Arosio, S. Mann, “Reconstitution of Manganese Oxide Cores in Horse Spleen and Recombinant Ferritins” Journal of Inorganic Biochemistry, (1995) 58 59-68.
Initial Assessment of Magnetoferritin Biokinetics and Proton Relaxation Enhancement in Rats
J.W.M. Bulte, T. Douglas, S. Mann, J. Vymazal, P.G. Laughlin, J.A. Frank, “Initial Assessment of Magnetoferritin Biokinetics and Proton Relaxation Enhancement in Rats” Academic Radiology (1995) 2 871-878.
Classical and Quantum Magnetic Phenomena in Natural and Artificial Ferritin Proteins
S. Gider, D. D. Awschalom, T. Douglas, S. Mann, M. Chaparala, “Classical and Quantum Magnetic Phenomena in Natural and Artificial Ferritin Proteins”, Science (1995) 268, 77-80.
Synthesis and Structure of an Iron(III) Sulfide-Ferritin Bioinorganic Nanocomposite
T. Douglas, D.P.E. Dickson, S. Betteridge, J. Charnock, C. D. Garner, S. Mann, “Synthesis and Structure of an Iron(III) Sulfide-Ferritin Bioinorganic Nanocomposite”, Science (1995), 269, 54-57.
Mössbauer Spectroscopic (and Magnetic) Studies of Magnetoferritin
Q.A. Pankhurst, S. Betteridge, D.P.E. Dickson, T. Douglas, S. Mann, R.B. Frankel, “Mössbauer Spectroscopic (and Magnetic) Studies of Magnetoferritin”, Hyperfine Interactions (1994), 90, 847-851.
Persistent Oral Contrast Agent Lining the Intestine in Severe Mucosal Disease: Elucidation of the Radiographic Appearence
L.D. Ma, B. Jones, A.J. Lazenby, T. Douglas, J.W.M. Bulte, “Persistent Oral Contrast Agent Lining the Intestine in Severe Mucosal Disease: Elucidation of the Radiographic Appearence”, Radiology (1994) 191, 747-749.
Magnetoferritin: Biomineralization as a Novel Molecular Aproach in the Design of Iron Oxide-Based MR Contrast Agents
J.W.M. Bulte, T. Douglas, S. Mann, R.B. Frankel, B.M. Moskowitz, R.A. Brooks, C.D. Baumgarner, J. Vymazal, J.A. Frank,”Magnetoferritin: Biomineralization as a Novel Molecular Aproach in the Design of Iron Oxide-Based MR Contrast Agents”, Investigative Radiology (1994), 29, S214-S216.
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Magnetoferritin: Characterization of a Novel Superparamagnetic MR Contrast Agent
J.W.M. Bulte, T. Douglas, S. Mann, R.B. Frankel, B.M. Moskowitz, R.A. Brooks, C.D. Baumgarner, J. Vymazal, M-P. Strub, J.A. Frank, “Magnetoferritin: Characterization of a Novel Superparamagnetic MR Contrast Agent”, Journal of Magnetic Resonance Imaging (1994), 4, 497-505.
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Oriented Nucleation of Gypsum (CaSO4.2H2O) under Compressed Langmuir Monolayers
Trevor Douglas and Stephen Mann, “Oriented Nucleation of Gypsum (CaSO4.2H2O) under Compressed Langmuir Monolayers”, Materials Science and Engineering C1 (1994), 193-199.
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Further Characterization of forms of Hemosiderin in Iron-overloaded Tissues
R.J. Ward, M. Ramsey, D.P.E.Dickson, C. Hunt, T. Douglas, S. Mann, F. Aouad, T.J. Peters, R.R. Chrighton, “Further Characterization of forms of Hemosiderin in Iron-overloaded Tissues”, European Journal of Biochemistry (1994), 225, 187-194.
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Mineral Sculptures in Biology
T. Douglas and J. M. Didymus, “Mineral Sculptures in Biology”, Chemistry Review (1994), 4, 2-7.
Crystallization at Inorganic-Organic Interfaces: Biominerals and Biomimetic Synthesis
S. Mann, D.D. Archibald, J.M. Didymus, T. Douglas, B.R. Heywood, F.C. Meldrum, N.J. Reeves, “Crystallization at Inorganic-Organic Interfaces: Biominerals and Biomimetic Synthesis”, Science (1993), 261, 1286.
Synthesis and Studies of III-V Semiconductor Precursors; Preparation of Semiconductor Colloids
T. Douglas, “Synthesis and Studies of III-V Semiconductor Precursors; Preparation of Semiconductor Colloids”, Ph.D dissertation, Cornell University (1991).
Molecular Precursors for Indium Phosphide and Synthesis of Small Semiconductor Clusters in Solution
Douglas and K. H. Theopold, “Molecular Precursors for Indium Phosphide and Synthesis of Small Semiconductor Clusters in Solution”, Inorganic Chemistry, (1991), 30, 594.
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A Phospholyl Complex of Indium
T. Douglas, B. S. Haggerty, A. L. Rheingold, K. H. Theopold, “A Phospholyl Complex of Indium.”, Polyhedron, (1990), 9, 329.
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Organometallic Precursors for III-V Semiconductors
E. K. Byrne, T. Douglas, K. H. Theopold, “Organometallic Precursors for III-V Semiconductors”, Mat. Res. Soc. Symp. Proc, (1989), 131, 59.
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Synthesis and Crystal Structure of a Phospholyl Anion
T. Douglas and K. H. Theopold, “Synthesis and Crystal Structure of a Phospholyl Anion”, Angew. Chem. Int. Ed. Engl., (1989), 28, 1367.
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